Selected Publications

(For other publications from the Bonni lab click here)

Valnegri P, Huang J, Yamada T, Yang Y, Mejia LA, Cho HY, Oldenborg A, Bonni A. RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain. Nature Communication 2017 Nov 2;8(1):1271.

Yang Y, Yamada T, Hill KK, Hemberg M, Reddy NC, Cho HY, Guthrie AN, Oldenborg A, Heiney SA, Ohmae S, Medina JF, Holy TE, Bonni A. Chromatin remodeling inactivates activity genes and regulates neural coding. Science 2016 Jul 15;353(6296):300-5.

Jahani-Asl A, Yin H, Soleimani VD, Haque T, Luchman HA, Chang NC, Sincennes MC, Puram SV, Scott AM, Lorimer IA, Perkins TJ, Ligon KL, Weiss S, Rudnicki MA, Bonni A. Control of glioblastoma tumorigenesis by feed-forward cytokine signaling. Nature Neuroscience 2016 Jun;19(6):798-806. 

Huang J, Bonni A. A decade of the anaphase-promoting complex in the nervous system. Genes & Development 2016 Mar 15; 30(6): 622–638.

Huang J, Ikeuchi Y, Malumbres M, Bonni A. A Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain. Neuron 2015, 86(3):726–39. 

Gallardo G, Barowski J, Ravits J, Siddique T, Lingrel JB, Robertson J, Steen H, Bonni A. An α2-Na/K ATPase/α-adducin complex in astrocytes triggers non-cell autonomous neurodegeneration. Nature Neuroscience 2014, 17:1710-9. 

Yamada T, Yang Y, Hemberg M, Yoshida T, Cho HY, Murphy JP, Fioravante D, Regehr WG, Gygi SP, Georgopoulos K, Bonni A. Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain. Neuron 2014, 83:122-34. 

Zhang C, Mejia LA, Huang J, Valnegri P, Bennett EJ, Anckar J, Jahani-Asl A, Gallardo G, Ikeuchi Y, Yamada T, Rudnicki M, Harper JW, Bonni A. The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain. Neuron 2013, 78:986-93.

Ikeuchi Y, de la Torre-Ubieta L, Matsuda T, Steen H, Okazawa H, Bonni A. The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons. Cell Reports 2013, 4:879-89.

Huynh MA, Ikeuchi Y, Netherton S, de la Torre-Ubieta L, Kanadia R, Stegmuller J, Cepko C, Bonni S, Bonni A. An isoform-specific SnoN1-FOXO1 transcriptional repressor complex regulates neuronal morphogenesis and positioning in the mammalian brain. Neuron 2011, 69:930-44.

de la Torre-Ubieta, Bonni A. Transcriptional regulation of neuronal polarity and morphogenesis. Neuron 2011, 72:22-40.

Puram SV, Kim AH, Ikeuchi Y, Wilson-Grady JT, Merdes A, Gygi SP, Bonni A. A CaMKIIβ signaling pathway at the centrosome regulates dendrite patterning in the brain. Nature Neuroscience 2011, 14:973-8.

Litterman N, Ikeuchi Y, Gallardo G, O'Connell BC, Sowa ME, Gygi SP, Harper JW, Bonni A. An OBSL1-Cul7 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning. PLoS Biol 2011, 9:e1001060

Yang Y, Kim AH, Yamada T, Wu B, Bilimoria P, Ikeuchi Y, de la Iglesia N, Shen J, Bonni A. A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science 2009, 326:575-8.

Kim AH, Puram SV, Bilimoria PM, Ikeuchi Y, Keough S, Wong M, Rowitch D, Bonni A. A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Cell 2009; 136:322-36.

Yuan Z*, Becker E*, Merlo P, Yamada T, DiBacco S, Konishi Y, Schaefer E, Bonni A. Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons (*equal contribution). Science 2008; 319:1665-8.

Shalizi A*, Gaudillière B*, Yuan Z, Shirogane T, Stegmüller J, Ge Q, Tan Y, Schulman B, Harper JW, Bonni A. A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation (*equal contribution). Science 2006; 311:1012-1017.

Stegmüller J, Konishi Y, Huynh MA, Yuan Z, DiBacco S, Bonni A. Regulation of axonal morphogenesis by the Cdh1-APC target SnoN. Neuron 2006; 50:389-400.

Lasorella A, Stegmüller J, Guardavaccaro D, Liu G, Rothschild G, de la Torre-Ubieta L, Pagano M, Bonni A, Iavarone A. Degradation of Id2 by the anaphase promoting complex couples control of cell cycle and axonal growth. Nature 2006; 442: 471-474.

Lehtinen M*, Yuan Z*, Boag P, Yang Y, Villen J, Becker E, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, Bonni A. A conserved MST-FOXO signaling pathway mediates oxidative stress responses and extends lifespan (*equal contribution). Cell 2006; 125: 987-1001.

Becker E, Bonni A. Neural-specific activation of the mitochondrial apoptotic machinery. Neuron 2006; 49:655-662.

Konishi Y, Stegmüller J, Matsuda T, Bonni S, Bonni A. Cdh1-APC controls axonal growth and patterning in the mammalian brain. Science 2004, 303:1026-30.

Gaudillière B, Konishi Y, de la Iglesia N, Yao G, Bonni A. A CaMKII-NeuroD signaling pathway specifies dendritic morphogenesis. Neuron 2004, 41(2):229-41.